Hydrochloric Acid → (4-Benzylpiperazin-1-yl)acetic acid--hydrogen chloride (1/2)

HRID 275904Notes

Reaction equation

HRID 275904 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([O:17]CC)=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:20]>>[ClH:20].[ClH:20].[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][C:15]([OH:17])=[O:16])[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 5060109ethyl 2-(4-benzylpiperazin-1-yl)acetate

Product 1

HCID 18593173(4-Benzylpiperazin-1-yl)acetic acid--hydrogen chloride (1/2)Yield 77.4%

Procedure

Ethyl 4-benzylpiperazineacetate (2.38 g, 9.0 mmol) was added to 3M hydrochloric acid solution(12 ml), refluxed for 2 hours, stirred for 1 day at a room temperature, and then concentrated under reduced pressure. The resulting residue was dissolved in methanol and reconcentrated. The resulting solid was suspended in ethyl ether, filtered and dried under a reduced pressure to give 2.14 g of the titled compound. (Yield 77.4%)

Workup

  1. temperaturerefluxed for 2 hours
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe resulting residue was dissolved in methanol
  4. filtrationfiltered
  5. customdried under a reduced pressure

Sources & evidence

ORD record
ord-743c0934463345408f75148a814b92b4
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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