Ethyl bromoacetate → 1-Piperidineacetic acid, ethyl ester

HRID 275905Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 275905
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C1C=CC=CC=1.C(OCC)C>[N:1]1([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 7748Ethyl bromoacetateHCID 8082Piperidine

Produkt 1

HCID 6434661-Piperidineacetic acid, ethyl esterAusbeute 81,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 241BenzeneLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Piperidine(1.87 ml, 18.9 mmol) was added dropwise to a solution of ethyl bromoacetate(1 ml, 9.0 mmol) in benzene(9 ml), stirred for 2 hours at a room temperature, diluted with ethyl ether, washed with saturated NaCl solution. The separated organic layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure to give 1.26 g of the titled compound. (Yield 81.8%)

Aufarbeitung

  1. washwashed with saturated NaCl solution
  2. dry with materialThe separated organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-48732d13576143678ac59c9e360f283c
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06352993B1

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