Hydrochloric Acid → 2-(Piperidin-1-yl)acetic acid hydrochloride

HRID 275906Notes

Reaction equation

HRID 275906 reaction equation
[N:1]1([CH2:7][C:8]([O:10]CC)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:13]>>[ClH:13].[N:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 6434661-Piperidineacetic acid, ethyl ester

Product 1

HCID 2010962-(Piperidin-1-yl)acetic acid hydrochlorideYield 65.3%

Procedure

Ethyl 1-piperidineacetate (1.26 g, 7.4 mmol) was added to 3M hydrochloric acid solution (12 ml), which was then refluxed for 2 hours, stirred for 1 day at a room temperature, then concentrated under a reduced pressure. The resulting residue was dissolved in methanol and reconcentrated. The resulting solid was suspended in ethyl ether, filtered and dried under a reduced pressure to give 0.87 g of the titled compound. (Yield 65.3%). NMR(D2O): 1.0(m, 2H), 1.4(m, 4H), 2.5(m, 2H), 3.1(m, 2H), 3.5(s, 2H).

Workup

  1. temperaturewas then refluxed for 2 hours
  2. concentrationconcentrated under a reduced pressure
  3. dissolutionThe resulting residue was dissolved in methanol
  4. filtrationfiltered
  5. customdried under a reduced pressure

Sources & evidence

ORD record
ord-ac269f281e234ecfa6d720ca193a2e88
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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