Phosphorus oxychloride → HCID 18315740, compound

HRID 275928Notes

Reaction equation

HRID 275928 reaction equation
[CH3:1][C:2]1[C:3](O)=[N:4][C:5]([NH:9][C:10]2[S:11][CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=2)=[N:6][C:7]=1[CH3:8].P(Cl)(Cl)([Cl:24])=O>>[CH3:1][C:2]1[C:3]([Cl:24])=[N:4][C:5]([NH:9][C:10]2[S:11][CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=2)=[N:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178433129HCID 178433129, compound

Product 1

HCID 18315740HCID 18315740, compoundYield 50%

Procedure

The same procedures as in Step 3 of Example 22 were repeated using 5,6-dimethyl-2-(4-phenylthiazol-2-yl)amino-4-hydroxypyrimidine (5.6 g, 18.77 mmol) and phosphorus oxychloride(7 ml) to afford 3.0 g of the titled compound. (Yield: 50%)

Sources & evidence

ORD record
ord-d13b40225bb744b68c9b8a4f2831c8bd
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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