Acetyl chloride → HCID 18315755, compound

HRID 275962Notes

Reaction equation

HRID 275962 reaction equation
[C:1]([Cl:4])(=[O:3])[CH3:2].C(N(CC)CC)C.[OH:12][CH2:13][C:14]1[C:15]([N:29]2[CH2:38][CH2:37][C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]2[CH3:39])=[N:16][C:17]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)=[N:18][C:19]=1[CH3:20]>ClCCl>[ClH:4].[ClH:4].[C:1]([O:12][CH2:13][C:14]1[C:15]([N:29]2[CH2:38][CH2:37][C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]2[CH3:39])=[N:16][C:17]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)=[N:18][C:19]=1[CH3:20])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 18613781HCID 18613781, compound

Product 1

HCID 18315755HCID 18315755, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetylchloride (2.71 μ1, 39.6 μmol) and triethylamine (20 μl, 142.6 μmol) were added to a suspension of 5-hydroxymethyl-6-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-(4-fluorophenylamino)pyrimidine (10 mg, 26.4 μmol) in dichloromethane(1 ml) and stirred for 1 day at a room temperature. The reaction mixture was purified by a silica gel column chromatography (ethylacetate/n-hexane=1/1) to give the titled compound.

Workup

  1. customThe reaction mixture was purified by a silica gel column chromatography (ethylacetate/n-hexane=1/1)

Sources & evidence

ORD record
ord-7db3682f06ed4e809707e295a711a66f
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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