Methyl 3-chloro-4-hydroxyphenylacetate → 3-Chloro-4-(3'-chloro-4'-isobutoxybenzyloxy) phenylacetic acid

HRID 27599Notes

Reaction equation

HRID 27599 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:5]Cl.[Cl:15][C:16]1[CH:17]=[C:18]([CH2:23][C:24]([O:26]C)=[O:25])[CH:19]=[CH:20][C:21]=1[OH:22]>CO.O>[Cl:15][C:16]1[CH:17]=[C:18]([CH2:23][C:24]([OH:26])=[O:25])[CH:19]=[CH:20][C:21]=1[O:22][CH2:5][C:4]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH:12]([CH3:13])[CH3:14])=[C:2]([Cl:1])[CH:3]=1

Participants

4

Reactant 2

HCID 92625Methyl 3-chloro-4-hydroxyphenylacetateHCID 123479393-Chloro-4-isobutyoxybenzyl chloride

Product 1

HCID 537586583-Chloro-4-(3'-chloro-4'-isobutoxybenzyloxy) phenylacetic acid

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

The procedure of Example (1) (e) was repeated wherein 3-chloro-4-isobutyoxybenzyl chloride was reacted with methyl 3-chloro-4-hydroxyphenylacetate to yield 3-chloro-4-(3'-chloro-4'-isobutoxybenzyloxy) phenylacetic acid (52.4yield), m.p. 127.5°-129° C. (methanol-water).

Sources & evidence

ORD record
ord-ed19a95cc9c14b48830e71430588f306
Source dataset
uspto-grants-1980_09
Patent number
US04221919

Reaction notes

Loading…