反应详情

To a stirred solution of 2,5-dimethylaniline (5.30 g) and 4-dimethylaminopyridine (6.41 g) in dichloromethane (90 ml) was added acetic anhydride (4.13 ml) under ice-cooling, and the mixture was stirred for 4 hours. The reaction mixture was washed with 1N hydrochloric acid and a saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate. Removal of the solvent in vacuo gave 2′,5′-dimethylacetanilide (6.09 g).

1. temperaturecooling
2. washThe reaction mixture was washed with 1N hydrochloric acid
3. dry with materiala saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate
4. customRemoval of the solvent in vacuo