HCID 10717980, compound → ethyl N-[2,6-dichloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate hydrochloride

HRID 275998Notes

Reaction equation

HRID 275998 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][NH:10][C@@H:11]([CH3:21])[C@H:12]([OH:20])[C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)[CH:5]=[C:4]([Cl:22])[C:3]=1[NH:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26]>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][NH:10][C@@H:11]([CH3:21])[C@H:12]([OH:20])[C:13]2[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=2)[CH:5]=[C:4]([Cl:22])[C:3]=1[NH:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26]

Participants

3

Reactant 1

HCID 10717980HCID 10717980, compound

Product 1

HCID 69991507ethyl N-[2,6-dichloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution of ethyl N-[2,6-dichloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]-ethyl]phenyl]aminoacetate (87 ml) in ethyl acetate (2.0 ml) was added 2.6 M hydrogen chloride diethyl ether solution (2.0 ml) at room temperature. Collection of the resulting precipitates by filtration gave ethyl N-[2,6-dichloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate hydrochloride (81 mg).

Workup

  1. customCollection of the resulting
  2. customprecipitates by filtration

Sources & evidence

ORD record
ord-6be260ff72434450bea2ef068e5d05ec
Source dataset
uspto-grants-2002_03
Patent number
US06353025B1

Reaction notes

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