反应详情

Ethyl N-[2,6-dichloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate (500 mg) was dissolved in 1N aqueous sodium hydroxide solution (5.0 ml), and the solution was stirred for 1 hour at room temperature. To the reaction mixture was added 1N hydrochloric acid (5.0 ml) under ice-cooling with stirring, and collection of the resulting precipitates by filtration gave N-[2,6-dichloro-4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-aminoacetic acid (464 mg).

1. temperaturecooling
2. stirringwith stirring
3. customcollection of the resulting
4. customprecipitates by filtration