反应详情

Seven-hundred milligrams of 6-tert-butoxycarbonylamino-1-(2-chlorobenzyl)-2-n-propylbenzimidazole were dissolved in a mixed solvent of 10 ml of methylene chloride and 1 ml of trifluoroacetic acid, and the mixture was stirred at room temperature for 5 hours. A small amount of methylene chloride was added to the reaction solution. The mixture was washed with a sodium carbonate aqueous solution, and was dried. The solvent was then distilled off. The residue was crystallized from a mixed solvent of n-hexane and ether to give 455 mg of 6-amino-1-(2-chlorobenzyl)-2-n-propylbenzimidazole (90).

1. washThe mixture was washed with a sodium carbonate aqueous solution
2. customwas dried
3. distillationThe solvent was then distilled off
4. customThe residue was crystallized from a mixed solvent of n-hexane and ether