Hydrochloric Acid → HCID 18681093, compound

HRID 276030Notes

Reaction equation

HRID 276030 reaction equation
[OH-].[Na+].C(O)C.[CH2:6]([N:13]1[C:17]2[CH:18]=[C:19]([C:22]([O:24]CC)=[O:23])[CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:27][CH2:28][CH3:29])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.Cl>O>[CH2:6]([N:13]1[C:17]2[CH:18]=[C:19]([C:22]([OH:24])=[O:23])[CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:27][CH2:28][CH3:29])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 18681060HCID 18681060, compound

Product 1

HCID 18681093HCID 18681093, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 10% sodium hydroxide aqueous solution (3.61 g), 5 ml of ethanol and 3 ml of water were added to 0.97 g of 1-benzyl-6-ethoxycarbonyl-2-n-propylbenzimidazole, and the mixture was heat-refluxed for 1 hour. The reaction solution was adjusted to a pH of 6 with 10% hydrochloric acid, and was concentrated under reduced pressure. Ethanol was added to the residue, and the inorganic salt was separated through filtration. The filtrate was concentrated under reduced pressure to give 0.85 g of 1-benzyl-6-carboxy-2-n-propylbenzimidazole (126).

Workup

  1. temperaturethe mixture was heat-refluxed for 1 hour
  2. concentrationwas concentrated under reduced pressure
  3. additionEthanol was added to the residue
  4. customthe inorganic salt was separated through filtration
  5. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-24eef85fcde644af943d257c4b3961d7
Source dataset
uspto-grants-2002_03
Patent number
US06352985B1

Reaction notes

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