Hydrochloric Acid → HCID 53819814, compound

HRID 276053Notes

Reaction equation

HRID 276053 reaction equation
[OH-].[K+].[CH3:3]I.[C:5]1([S:11]([NH:14][C:15]([C:17]2[CH:18]=[CH:19][C:20]3[N:24]=[C:23]([SH:25])[N:22]([CH2:26][C:27]4[CH:32]=[CH:31][C:30]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)=[CH:29][CH:28]=4)[C:21]=3[CH:39]=2)=[O:16])(=[O:13])=[O:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl>CO.O>[C:5]1([S:11]([NH:14][C:15]([C:17]2[CH:18]=[CH:19][C:20]3[N:24]=[C:23]([S:25][CH3:3])[N:22]([CH2:26][C:27]4[CH:28]=[CH:29][C:30]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)=[CH:31][CH:32]=4)[C:21]=3[CH:39]=2)=[O:16])(=[O:13])=[O:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 178523998HCID 178523998, compound

Product 1

HCID 53819814HCID 53819814, compoundYield 88.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A 20% potassium hydroxide aqueous solution (0.323 g), 2 ml of water and 0.123 g of methyl iodide were added to a solution of 0.310 g of 6-benzenesulfonylcarbamoyl-1-(biphenyl-4-ylmethyl)-2-mercaptobenzimidazole in 5 ml of methanol in this order, and the mixture was stirred at room temperature for 2 hours. The reaction solution was adjusted to a pH of from 5 to 6 with 10% hydrochloric acid. The crystals precipitated were separated through filtration, and were dried to give 0.281 g of 6-benzenesulfonylcarbamoyl-1-(biphenyl-4-ylmethyl)-2-methylthio-benzimidazole (237).

Workup

  1. customThe crystals precipitated
  2. customwere separated through filtration
  3. customwere dried

Sources & evidence

ORD record
ord-c2e46bd6392f45e7816574718192cf7c
Source dataset
uspto-grants-2002_03
Patent number
US06352985B1

Reaction notes

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