Hydrazine hydrate (1:1) → HCID 11230848, compound

HRID 276105Notes

Reaction equation

HRID 276105 reaction equation
[CH3:1][C:2]1[CH:18]=[C:17]([CH3:19])[CH:16]=[C:15]([CH3:20])[C:3]=1[C:4]([C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8](O)=[O:9])=O.O.[NH2:22][NH2:23]>CCO>[CH3:1][C:2]1[CH:18]=[C:17]([CH3:19])[CH:16]=[C:15]([CH3:20])[C:3]=1[C:4]1[C:6]2[C:7](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:8](=[O:9])[NH:23][N:22]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 348957MLS003373803

Product 1

HCID 11230848HCID 11230848, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(2,4,6-trimethylbenzoyl-benzoic acid (5.0 g, 18.7 mmol) and hydrazine hydrate (2 mL) in 15 mL of EtOH was stirred at reflux for 8. hours. The solvent was then removed from the mixture. The residue was heated to melt for about 10 minutes and then solidified by cooling. The resulting yellow solids were triturated with ether and filtered. The solid was washed with 1 N NaOH and water, and dried to give 1.8 g of titled compound as yellow solids, m.p. 259-62° C.

Workup

  1. temperatureat reflux for 8
  2. customThe solvent was then removed from the mixture
  3. temperatureThe residue was heated
  4. temperatureby cooling
  5. customThe resulting yellow solids were triturated with ether
  6. filtrationfiltered
  7. washThe solid was washed with 1 N NaOH and water
  8. customdried

Sources & evidence

ORD record
ord-9aea4a2178894a4e8d9189afe8203385
Source dataset
uspto-grants-2002_03
Patent number
US06353103B1

Reaction notes

Loading…