Sodium Methoxide → HCID 18316937, compound

HRID 276107Notes

Reaction equation

HRID 276107 reaction equation
CC1C=CC(S(O[N:12]=[C:13]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH3:14])(=O)=O)=CC=1.C[O-].[Na+]>CO>[N:12]1[CH2:14][C:13]=1[C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 85394088HCID 85394088, compound

Product 1

HCID 18316937HCID 18316937, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A more particular subject of the invention is a process characterized in that 1-(3-pyridinyl)-ethanone O-[(4-methylphenyl) sulphonyl] oxime is subjected to the action of methanol and sodium methylate in order to obtain 3-(2H-azirin-3-yl)-pyridine which is subjected to the action of oxalic acid in order to obtain β,β-dimethoxy-2-(3-pyridinyl)ethyl)-amine which is subjected to the action of formamide in order to obtain N-[β,β-dimethoxy-2-(3-pyridinyl)ethyl]-formamide which is subjected to a cyclization in order to obtain the sought product.

Sources & evidence

ORD record
ord-c559ca488bd94680b8c0e49f0d5bf0a6
Source dataset
uspto-grants-2002_03
Patent number
US06353108B1

Reaction notes

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