Aluminium lithium hydride → 2,8-Dichloro-10,11-dihydro-11-(4-pyridyl)dibenz[b,f][1,4]oxazepine

HRID 27626Notes

Reaction equation

HRID 27626 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:9]=3[N:8]=[C:7]([C:17]3[CH2:18][CH2:19][N:20](C)[CH2:21][CH:22]=3)[C:6]=2[CH:24]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:9]=3[NH:8][CH:7]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[C:6]=2[CH:24]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 233426472,8-Dichloro-11-(1,2,3,6-tetrahydro-1-methyl-4-pyridyl)-dibenz[b,f][1,4]oxazepine

Product 1

HCID 233426652,8-Dichloro-10,11-dihydro-11-(4-pyridyl)dibenz[b,f][1,4]oxazepine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A 20.0 g. portion of 2,8-dichloro-11-(4-pyridyl)-dibenz[b,f][1,4]oxazepine (Example 2), 10.0 g. of lithium aluminum hydride and 800 ml. of ether are reacted as described in Example 3, yielding 2,8-dichloro-10,11-dihydro-11-(4-pyridyl)-dibenz[b,f][1,4]oxazepine, mp. 202°-205° C.

Sources & evidence

ORD record
ord-6378e3ea413148dc9987027b6b2a6ede
Source dataset
uspto-grants-1980_09
Patent number
US04221714

Reaction notes

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