1-Bromo-2-methylpropane → HCID 54520243, compound

HRID 276292Notes

Reaction equation

HRID 276292 reaction equation
[CH:1]([C@H:4]1[CH2:9][CH2:8][S:7][C:6](=[N:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:12]=2[CH3:20])[NH:5]1)([CH3:3])[CH3:2].[CH2:21](Br)[CH:22]([CH3:24])[CH3:23]>>[CH2:21]([N:5]1[C@@H:4]([CH:1]([CH3:3])[CH3:2])[CH2:9][CH2:8][S:7][C:6]1=[N:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:12]=1[CH3:20])[CH:22]([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 178428752HCID 178428752, compound

Product 1

HCID 54520243HCID 54520243, compoundYield 32%

Procedure

(R)-4-Isopropyl-2-(2-methyl-4-nitrophenylimino)-2,3,4,5-tetrahydro-1,3-thiazine Method C3a) was reacted with isobutyl bromide in a manner analogous to Method D2a to yield (4R)-3-isobutyl-4-isopropyl-2-(2-methyl-4-nitrophenylimino)tetrahydro-2H-1,3-thiazine (0.081 g, 32%). TLC (33% EtOAc/hex) Rf0.76.

Sources & evidence

ORD record
ord-53c8216a93a94c1b826138981909adc8
Source dataset
uspto-grants-2002_03
Patent number
US06353006B1

Reaction notes

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