1-Amino-2-propanol → HCID 178428747, compound

HRID 276509Notes

Reaction equation

HRID 276509 reaction equation
O[CH:2]([CH3:5])[CH2:3][NH2:4].[Cl-].ClC(C)C[NH3+].[CH3:12][C:13]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[CH:15][C:14]=1[N:22]=[C:23]=[S:24]>>[CH3:12][C:13]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[CH:15][C:14]=1[N:22]=[C:23]1[NH:4][CH2:3][CH:2]([CH3:5])[S:24]1

Participants

4

Reactant 3

HCID 41-Amino-2-propanolHCID 1456212-Methyl-4-nitrophenyl isothiocyanateHCID 178456128HCID 178456128, compound2×

Product 1

HCID 178428747HCID 178428747, compound

Procedure

2-Hydroxypropylamine was converted to 2-chloropropylammonium chloride according to Method B7a. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with 2-chloropropylammonium chloride according to Method C1a to give 2-(2-methyl-4-nitrophenylimino)-5-methyl-1,3-thiazolidine. The thiazolidine was reacted with 2-methylprop-2-en-1-yl bromide according to Method D2g to afford 2-(2-methyl-4-nitrophenylimino)-3-(2-methylprop-2-en-1-yl)-5-methyl-1,3-thiazolidine HBr salt.

Sources & evidence

ORD record
ord-401eebb10b634fcbb0e43f7595770f68
Source dataset
uspto-grants-2002_03
Patent number
US06353006B1

Reaction notes

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