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HRID27655

反应详情

EQUATION

反应方程式

HRID 27655 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：Nc1ccc(O)cc1
HCID403

4-Aminophenol

C6H7NO

结构：O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1
HCID7404

Benzenesulfonyl chloride, 4-nitro-

C6H4ClNO4S

PRODUCTS

生成物

1
结构：O=[N+]([O-])c1ccc(S(=O)(=O)Nc2ccc(O)cc2)cc1
HCID352935

N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide

C12H10N2O5S

收率 73%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A mixture of 4-aminophenol (27 g, 0.25 mole) and 4-nitrobenzenesulfonyl chloride (55 g, 0.25 mole) in pyridine (500 ml) was heated under reflux for 4 hours. The reaction mixture was poured in ice water and acidified with acetic acid. The crude product weighed 86 g. Recrystallization from CH3NO2 provided 53 g (73%) of material used in Part B; m.p. 197°-198°.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. customRecrystallization from CH3NO2