3-Bromo-2-methyl-1-propene → HCID 18316302, compound

HRID 276593Notes

Reaction equation

HRID 276593 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[S:16][CH2:15][C:14]2([CH2:20][CH2:19][CH2:18][CH2:17]2)[NH:13]1.Br[CH2:22][C:23]([CH3:25])=[CH2:24]>>[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[S:16][CH2:15][C:14]2([CH2:17][CH2:18][CH2:19][CH2:20]2)[N:13]1[CH2:24][C:23]([CH3:25])=[CH2:22]

Participants

3

Reactant 2

HCID 3577853-Bromo-2-methyl-1-propeneHCID 1784287362-(2-Methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane

Product 1

HCID 18316302HCID 18316302, compound

Procedure

1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was converted to 1-chloromethylcyclopentanamine HCl salt according to Method B7e. 1-Chloromethylcyclopentanamine HCl salt was reacted with 2-methyl-4-nitrophenyl isothiocyanate according to Method C1e to give 2-(2-methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with 3-bromo-2-methylpropene according to Method D2e to give 2-(2-methyl-4-nitrophenylimino)-1-(2-methylprop-1-en-3-yl)-3-thia-1-azaspiro[4.4]nonane.

Sources & evidence

ORD record
ord-163ea2e7fbc143c182fcf1abd782ef28
Source dataset
uspto-grants-2002_03
Patent number
US06353006B1

Reaction notes

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