3-Bromo-2-methyl-1-propene → HCID 18316302, compound

Participants

Reaction Steps

1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was converted to 1-chloromethylcyclopentanamine HCl salt according to Method B7e. 1-Chloromethylcyclopentanamine HCl salt was reacted with 2-methyl-4-nitrophenyl isothiocyanate according to Method C1e to give 2-(2-methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with 3-bromo-2-methylpropene according to Method D2e to give 2-(2-methyl-4-nitrophenylimino)-1-(2-methylprop-1-en-3-yl)-3-thia-1-azaspiro[4.4]nonane.

Provenance & Evidence