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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 27669Generated: October 29, 2026

N-(3-Carbomethoxy-5-methyl-2-thienyl)-2-methylpropanamide → 2-Methyl-N-(5-methylthiophen-2-yl)propanamide

https://huagongshe.com/reaction/27669

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(3-Carbomethoxy-5-methyl-2-thienyl)-2-methylpropanamideHCID 23341602—
ReactantLithium iodide (LiI), dihydrateHCID 23688289—
Product2-Methyl-N-(5-methylthiophen-2-yl)propanamideHCID 2334162854%

Reaction Steps

The ester from Example 48 was treated with lithium iodide dihydrate as in Example 42 to give the expected decarboxylated product, N-(5-methyl-2-thienyl)-2-methylpropanamide, m.p. 96°-97° C. in 54% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04222946
Source datasetuspto-grants-1980_09
ORD IDord-5f00fe46fc7546ada4e1eced6353c3b3
Source noteuspto-grants-1980_09