HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chlorothieno[3,2-b]pyridine-2-sulfonyl chloride → 5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chlorothieno[3,2-b]pyridine-2-sulfonyl chloride | HCID 22017299 | — |
| Reactant | 4-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2carbonitrile hydrochloride | HCID 22883629 | — |
| Product | 5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide | HCID 54379487 | — |
Reaction Steps
The title compound is prepared from 4-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2carbonitrile hydrochloride as described in EXAMPLE 1, Part E using 5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride in place of benzo[b]thiophene-2-sulfonyl chloride. The product is triturated with Et2O/CH2Cl2 /hexanes to give a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05731315 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-394fa6eeedf64e31a0dbc91c22f2c1e3 |
| Source note | uspto-grants-1998_03 |