反应详情

N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl}-4-bromomethyl-benzamide (0.18 mmol) is dissolved in THF (1 ml) and sodium-imidazol (0.41 mmol) is added and the reaction mixture stirred at RT over night. After evaporation of the solvent, the residue is extracted with ethyl acetate. The extract is washed with water, dried over magnesium sulfate and evaporated. An oil with Rf=0.44 (CH2Cl2/MeOH=9:1) is obtained.

1. customAfter evaporation of the solvent
2. extractionthe residue is extracted with ethyl acetate
3. washThe extract is washed with water
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customAn oil with Rf=0.44 (CH2Cl2/MeOH=9:1) is obtained