反应详情

温度

40 °C

4-Mercaptobenzoic acid (65 mmol) and 1-Bromo-2-chloro-ethane (71 mmol) are dissolved in acetone (120 ml) and powdered potassium carbonate (71 mmol) is added. The mixture is warmed up to 40° C. and stirred for 7 hours. After evaporation of the solvent, the residue is extracted with ethyl acetate. The extract is washed with water and dried over sodium sulfate and evaporated. The crude product is suspended in diethylether and the solid filtered of and dried (vacuum). 7.8 g of a white powder with mp. 142-144° C., Rf=0.37 (methylenchlorid/methanol=9/1) is obtained.

1. customAfter evaporation of the solvent
2. extractionthe residue is extracted with ethyl acetate
3. washThe extract is washed with water
4. dry with materialdried over sodium sulfate
5. customevaporated
6. filtrationthe solid filtered of and
7. customdried (vacuum)