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Allyl bromide → 3-Chloromethyl-benzoic acid allyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Allyl bromide | HCID 7841 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-(Chloromethyl)benzoic acid | HCID 241752 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 3-Chloromethyl-benzoic acid allyl ester | HCID 11424370 | — |
反応手順
A solution of 3-(chloromethyl)-benzoic acid (50.0 g, 0.293 mol), potassium carbonate (48.61 g, 0.352 mol) and allyl bromide (50.7 mL, 0.586 mol) in acetone (500 mL) is refluxed for 2 hours, after which time the solution was cooled to room temp. and filtered through celite. The filtrate is evaporated and the residue chromatographed (silica, 5% EtOAc/hexane) to yield allyl 3-(chloromethyl)-benzoate as a clear oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353017B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-cf5788fce5884aba8062303175a062fa |
| 出典メモ | uspto-grants-2002_03 |