反应详情

A solution of 3-(chloromethyl)-benzoic acid (50.0 g, 0.293 mol), potassium carbonate (48.61 g, 0.352 mol) and allyl bromide (50.7 mL, 0.586 mol) in acetone (500 mL) is refluxed for 2 hours, after which time the solution was cooled to room temp. and filtered through celite. The filtrate is evaporated and the residue chromatographed (silica, 5% EtOAc/hexane) to yield allyl 3-(chloromethyl)-benzoate as a clear oil.

1. temperatureafter which time the solution was cooled to room temp.
2. filtrationfiltered through celite
3. customThe filtrate is evaporated
4. customthe residue chromatographed (silica, 5% EtOAc/hexane)