反应详情

A solution of methyl 3-(2-bromoethoxy)-benzoate (2.4 g, 9.26 mmol) and sodium iodide (2.78 g, 18.52 mmol) in acetone (50 mL) is refluxed for 2 hours. The resulting mixture is then filtered and concentrated. The residue is diluted with EtOAc (100 mL), washed with 5% Na2SO3 (50 mL), water (2×50 mL) and brine (50 mL), dried over MgSO4 and evaporated to yield methyl 3-(2-iodoethoxy)-benzoate, as a yellow oil, which is used directly.

1. filtrationThe resulting mixture is then filtered
2. concentrationconcentrated
3. additionThe residue is diluted with EtOAc (100 mL)
4. washwashed with 5% Na2SO3 (50 mL), water (2×50 mL) and brine (50 mL)
5. dry with materialdried over MgSO4
6. customevaporated