Hydrochloric Acid → HCID 18671509, compound

Participants

Reaction Steps

A 1N solution of HCl in diethyl ether (0.96 mL, 0.96 mmol) was added via syringe to a solution of 2-(4-{-[5(3,4-Dichloro-phenyl)-1H-imidazol-2-yl]-pyridin-2-yl}-piperazin-1-yl)-ethanol (403 mg, 0.96 mmol) in methanol (10 mL). The resultant solution was stirred for 5 min at ambient temperature and then concentrated to provide 2-(4-{5-[5(3,4-Dichloro-phenyl)-1H-imidazol-2-yl]-pyridin-2-yl}-piperazin-1-yl)-ethanol; hydrochloride (409 mg). MS m/z 418 (M++1 for free base).

Provenance & Evidence