Hydrochloric Acid → HCID 18671509, compound

HRID 276784Notes

Reaction equation

HRID 276784 reaction equation
[ClH:1].C(O[CH2:5][CH3:6])C.Cl[C:8]1[CH:9]=[C:10]([C:15]2[NH:19][C:18]([C:20]3[C:21](N4CCN(CCO)CC4)=[N:22][CH:23]=[CH:24][CH:25]=3)=[N:17][CH:16]=2)[CH:11]=[CH:12][C:13]=1[Cl:14].[CH3:35][OH:36]>>[Cl:1][C:12]1[CH:11]=[C:10]([C:15]2[NH:19][C:18]([C:20]3[CH:25]=[CH:24][C:23]([N:19]4[CH2:6][CH2:5][N:17]([CH2:18][CH2:35][OH:36])[CH2:16][CH2:15]4)=[N:22][CH:21]=3)=[N:17][CH:16]=2)[CH:9]=[CH:8][C:13]=1[Cl:14]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3283Diethyl EtherHCID 22629100HCID 22629100, compound

Product 1

HCID 18671509HCID 18671509, compound

Procedure

A 1N solution of HCl in diethyl ether (0.96 mL, 0.96 mmol) was added via syringe to a solution of 2-(4-{-[5(3,4-Dichloro-phenyl)-1H-imidazol-2-yl]-pyridin-2-yl}-piperazin-1-yl)-ethanol (403 mg, 0.96 mmol) in methanol (10 mL). The resultant solution was stirred for 5 min at ambient temperature and then concentrated to provide 2-(4-{5-[5(3,4-Dichloro-phenyl)-1H-imidazol-2-yl]-pyridin-2-yl}-piperazin-1-yl)-ethanol; hydrochloride (409 mg). MS m/z 418 (M++1 for free base).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-51249056b04e469fa1447683b11e80ee
Source dataset
uspto-grants-2002_03
Patent number
US06355635B1

Reaction notes

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