反应详情

温度

25 °C

To 1-(4′-Cyanobenzyl)imidazol-5-ylmethyl piperazine prepared as described in EXAMPLE 2 (0.416 mmol) in methylene chloride was added DIEA (0.832 mmol) and commercially available neopentyl chloroformate (0.499 mmol). This solution was stirred for 2 hours at 25° C. and then the title compound was purified on preparative hpic and isolated via lyophilization. FAB-MS: calc: 395.5 found: 396.2. 1H-NMR (CD3OD): 8.9 ppm (s, 1H); 7.8 ppm (d, 2H); 7.5 ppm (s, 1H); 7.45 ppm (d, 2H); 5.65 ppm (s, 2H); 3.8 ppm (s, 2H); 3.45 ppm (s, 2H); 3.3 ppm (m, 4H): 2.3 ppm (m, 4H); 0.95 ppm (m, 9H).

1. customthe title compound was purified on preparative hpic and
2. customisolated via lyophilization