反应详情

1.1 g (4.8 mM) of 1-(2-aminoethyl)-4-(2-methoxyphenyl)-piperazine were added to 1.6 g (4.8 mM) of 2-ethoxymethyleneamino-3,5-dicarbethoxy-4,6-dihydrothieno[3,2-c]pyrrole in 25 ml of ethanol and refluxed for 2 h. The mixture was then concentrated in a rotary evaporator, and the crude product was purified by column chromatography (silica gel, mobile phase methylene chloride/methanol 96/4). After recrystallization from ethyl acetate, 1.1 g (47%) of product were isolated with melting point 153-155° C.

1. temperaturerefluxed for 2 h
2. concentrationThe mixture was then concentrated in a rotary evaporator
3. customthe crude product was purified by column chromatography (silica gel, mobile phase methylene chloride/methanol 96/4)
4. customAfter recrystallization from ethyl acetate