1-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazine → 3,4,5,7-Tetrahydro-6-carbethoxy-3-[2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl]pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-one

Participants

Reaction Steps

1.1 g (4.8 mM) of 1-(2-aminoethyl)-4-(2-methoxyphenyl)-piperazine were added to 1.6 g (4.8 mM) of 2-ethoxymethyleneamino-3,5-dicarbethoxy-4,6-dihydrothieno[3,2-c]pyrrole in 25 ml of ethanol and refluxed for 2 h. The mixture was then concentrated in a rotary evaporator, and the crude product was purified by column chromatography (silica gel, mobile phase methylene chloride/methanol 96/4). After recrystallization from ethyl acetate, 1.1 g (47%) of product were isolated with melting point 153-155° C.

Provenance & Evidence