反应详情

A solution of 22.4 g (79.8 mmol) of 2-(2-chloro-5-nitro-pyridine-3-carbonyl)-3-dimethylamino-acrylonitrile was refluxed in a mixture of 500 ml of ethanol and 180 ml of conc. ammonium hydroxide for 2 hr. The mixture was cooled and solid was collected which was washed with ether. Concentrating the filtrate gave a second crop which was collected and washed with ether. Solids were combined. After drying, 19.3 g of the title compound was obtained as a yellow solid: mass spectrum (electrospray, m/e): M−H 215 (negative mode).

1. temperatureThe mixture was cooled
2. customsolid was collected which
3. washwas washed with ether
4. concentrationConcentrating the filtrate
5. customgave a second crop which
6. customwas collected
7. washwashed with ether
8. customAfter drying