反应详情

To 250 mg of 4-(2,4-dichloro-phenylamino)-6-fluoro-[1.7]naphthyridine-3-carbonitrile under an inert atmosphere was added 8 mL of 1 M sodium (2-dimethylamino-ethoxide) in tetrahydrofuran. After refluxing for 2 hours, the reaction was stripped of tetrahydrofuran and water was added. The product was filtered, washed with water, dried, and recrystallized from chloroform/ether/hexanes to give 186 mg (59%) of 4-(2,4-dichloro-phenylamino)-6-(2-dimethylamino-ethoxy)-[1.7]naphthyridine-3-carbonitrile as a yellow solid: melting point 75-9° C.; mass spectrum (m/e): M+H 401.9.

1. temperatureAfter refluxing for 2 hours
2. additionwas added
3. filtrationThe product was filtered
4. washwashed with water
5. customdried
6. customrecrystallized from chloroform/ether/hexanes