反应详情

1-t-Butoxycarbonyl-4-hydroxy-4-(2-methoxyphenyl)piperidine (230 mg, 0.75 mmol) was dissolved in methylene chloride (10 ml). Thereto was added trifluoroacetic acid (0.20 ml, 2.6 mmol) and the resulting solution was stirred at a room temperature for 2.5 hours. The reaction solution was washed with saturated sodium bicarbonate aqueous solution and saturated brine in that order and dried with anhydrous sodium sulfate. Then the compound obtained by the evaporation of the solvent under a reduced pressure was separated and purified by a silica gel column chromatography to obtain 150 mg of the aforementioned compound of interest (0.53 mmol, 71% in yield).

1. washThe reaction solution was washed with saturated sodium bicarbonate aqueous solution and saturated brine in that order
2. dry with materialdried with anhydrous sodium sulfate
3. customThen the compound obtained by the evaporation of the solvent under a reduced pressure
4. customwas separated
5. custompurified by a silica gel column chromatography
6. customto obtain