反应详情

Ethanol and Raney nickel slurry (Aldrich) were added to 1-methyl-benz[cd]indole-2(1H)-one (4.5 g, 25 mmol) to carry out catalytic reduction under ordinary pressure. The reaction was terminated when 1.15 L of hydrogen absorption was observed, Raney nickel was removed by filtration, the resulting filtrate was concentrated and then the thus obtained colorless oil was purified by a silica gel column chromatography to obtain 3.8 g of the title compound (20 mmol, 80% in yield).

1. customThe reaction was terminated
2. customwhen 1.15 L of hydrogen absorption
3. customRaney nickel was removed by filtration
4. concentrationthe resulting filtrate was concentrated
5. customthe thus obtained colorless oil was purified by a silica gel column chromatography