Benz[cd]indol-2(1H)-one, 1-methyl- → Benz(cd)indol-2(1H)-one, 2a,3,4,5-tetrahydro-1-methyl-

Participants

Reaction Steps

Ethanol and Raney nickel slurry (Aldrich) were added to 1-methyl-benz[cd]indole-2(1H)-one (4.5 g, 25 mmol) to carry out catalytic reduction under ordinary pressure. The reaction was terminated when 1.15 L of hydrogen absorption was observed, Raney nickel was removed by filtration, the resulting filtrate was concentrated and then the thus obtained colorless oil was purified by a silica gel column chromatography to obtain 3.8 g of the title compound (20 mmol, 80% in yield).

Provenance & Evidence