反应详情

温度

100 °C

A mixture of 72.5 mg (0.25 mmol) 7-bromo-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, 37.4 mg (0.275 mmol) p-methoxy-boronic acid, and 0.22 ml 2M Na2CO3 in 0.78 ml dioxane was treated with 0.05 eq. dichloro (1,1′-bis(diphenylphosphino) ferrocene)palladium (II) dichloromethane adduct and heated to 100° C. for 15 h. Formic acid was added and the mixture was purified by reversed phase column chromatography eluting with an acetonitrile/water gradient yielding 13.3 mg (17%) of the title compound. MS m/e (%): 318 (M+H+, 100)

1. customthe mixture was purified by reversed phase column chromatography
2. washeluting with an acetonitrile/water gradient