Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 7-Bromo-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 22629706 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 44119782 | — |
| Product | HCID 18313597 | HCID 18313597 | 17% |
Reaction Steps
A mixture of 72.5 mg (0.25 mmol) 7-bromo-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, 37.4 mg (0.275 mmol) p-methoxy-boronic acid, and 0.22 ml 2M Na2CO3 in 0.78 ml dioxane was treated with 0.05 eq. dichloro (1,1′-bis(diphenylphosphino) ferrocene)palladium (II) dichloromethane adduct and heated to 100° C. for 15 h. Formic acid was added and the mixture was purified by reversed phase column chromatography eluting with an acetonitrile/water gradient yielding 13.3 mg (17%) of the title compound. MS m/e (%): 318 (M+H+, 100)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06355653B1 |
|---|
| Source dataset | uspto-grants-2002_03 |
|---|
| ORD ID | ord-1a95dd4fc8524259a4ad1ce44f7bd2f1 |
|---|
| Source note | uspto-grants-2002_03 |
|---|
