HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-methyl-2-pyrrolidone → 2-Furan-2-yl-7-(5,6,7,8-tetrahydro-naphthalen-2-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Edukt | 5,6,7,8-Tetrahydro-2-naphthol | HCID 14305 | — |
| Edukt | [1,2,4]Triazolo[1,5-a]pyridin-5-amine | HCID 22629716 | — |
| Produkt | 2-Furan-2-yl-7-(5,6,7,8-tetrahydro-naphthalen-2-yloxy)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 18313689 | — |
Reaktionsschritte
A mixture of 1 eq. 7-bromo-2-furan-2-)yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, 5 eq. 5,6,7,8-tetrahydro-naphthalen-2-ol and a catalytic amount of CS2CO3 in 200 μl N-methyl-pyrrolidon was heated for 2 h to 160°. The mixture was, after filtration, purified with reversed phase column chromatography eluting with an acetonitrile/water gradient yielding the title compound, MS m/e (%): 346 M+H+ (100%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06355653B1 |
| Quelldatensatz | uspto-grants-2002_03 |
| ORD ID | ord-48af4c44d81b490bb4074677e9860dfb |
| Quellennotiz | uspto-grants-2002_03 |