反应详情

A mixture of 1 eq. 7-bromo-2-furan-2-)yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, 5 eq. 5,6,7,8-tetrahydro-naphthalen-2-ol and a catalytic amount of CS2CO3 in 200 μl N-methyl-pyrrolidon was heated for 2 h to 160°. The mixture was, after filtration, purified with reversed phase column chromatography eluting with an acetonitrile/water gradient yielding the title compound, MS m/e (%): 346 M+H+ (100%).

1. additionA mixture of 1 eq
2. filtrationafter filtration
3. custompurified with reversed phase column chromatography
4. washeluting with an acetonitrile/water