HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 277122Generated: October 31, 2026
1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Pyrazol-1-yl-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine
https://huagongshe.com/reaction/277122
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Ethylacetate methanol | HCID 21584119 | — |
| Reactant | 2-Methanesulfinyl-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 22629703 | — |
| Solvent | Pyrazole | HCID 1048 | — |
| Product | 2-Pyrazol-1-yl-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 9882082 | 26% |
Reaction Steps
A mixture of 0.50 g (0.002 mol) 2-methanesulfinyl-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine and 0.33 ml (0.002 mol) 1,8-diazabicyclo[5.4.0]undec-7-en in 12.5 g molten pyrazole as solvent was stirred overnight at 120° C. Destillation of the solvent and chromatography on silicagel with ethylacetate/methanol 95/5 gave 0.13 g (26%) 2-pyrazol-1-yl-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine as a white solid, MS m/e (%):278 (M+H+,100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06355653B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-1d2e71b1dc364b6083a5cb32c5ab947d |
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| Source note | uspto-grants-2002_03 |
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