反应详情

温度

120 °C

A mixture of 0.50 g (0.002 mol) 2-methanesulfinyl-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine and 0.33 ml (0.002 mol) 1,8-diazabicyclo[5.4.0]undec-7-en in 12.5 g molten pyrazole as solvent was stirred overnight at 120° C. Destillation of the solvent and chromatography on silicagel with ethylacetate/methanol 95/5 gave 0.13 g (26%) 2-pyrazol-1-yl-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine as a white solid, MS m/e (%):278 (M+H+,100).