反应详情

温度

120 °C

A mixture of 2-(4-bromomethylphenyl)benzonitrile (12 g) and sodium bicarbonate (26 g) in dimethyl sulfoxide (150 ml) was heated at 120° C. for 5 hours with stirring. After addition of water, the mixture was extracted with ethyl acetate. The extract was washed with water, dried and concentrated to dryness. The residue was purified by column chromatography on silica gel to give crystals. Recrystallization from chloroform-isopropyl ether gave colorless needles (5.77 g, 63%).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. concentrationconcentrated to dryness
5. customThe residue was purified by column chromatography on silica gel
6. customto give crystals
7. customRecrystallization from chloroform-isopropyl ether