Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Epichlorohydrin → 1-(2-Methyl-4-hydroxynaphthoxy)-3-[4-(3,4-dimethoxyphenyl)-1-piperazinyl]propan-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Epichlorohydrin | HCID 7835 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(3,4-Dimethoxyphenyl)piperazine dihydrochloride | HCID 22625407 | — |
| 반응물 | 4-Benzoyloxy-2-methylnaphthol | HCID 22625409 | — |
| 생성물 | 1-(2-Methyl-4-hydroxynaphthoxy)-3-[4-(3,4-dimethoxyphenyl)-1-piperazinyl]propan-2-ol | HCID 22625385 | 8.8% |
반응 단계
Using 2.8 g (0.01 mol) of 4-benzoyloxy-2-methylnaphthol, 1.4 g (0.01 mol) of anhydrous potassium carbonate, 4.6 g (0.05 mol) of chloromethyloxirane, 2.9 g (0.01 mol) of 1-(3,4-dimethoxyphenyl)piperazine dihydrochloride and 2.0 g (0.02 mol) of triethylamine, reaction was carried out as in Examples 3 and 4 to give 0.4 g of white crystals, m.p. 180-182° C. (decomp.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06358515B2 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-ba651ba37ecd4920b08c5bcff6415d40 |
| 출처 메모 | uspto-grants-2002_03 |