Hydrazine hydrate (1:1) → 5-Cyano-6-methylidene-hydrazino-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

HRID 27764Notes

Reaction equation

HRID 27764 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:6]([NH:11][CH:12]([CH3:15])[CH2:13][CH3:14])=[N:7][C:8]=1[CH:9]=O)#[N:2].O.[NH2:22][NH2:23]>CO>[C:1]([C:3]1[C:8](=[CH2:9])[NH:7][C:6]([NH:11][CH:12]([CH3:15])[CH2:13][CH3:14])=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:4]=1[NH:22][NH2:23])#[N:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 867372205-Cyano-6-formyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

Product 1

HCID 867372215-Cyano-6-methylidene-hydrazino-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.8 g of 5-cyano-6-formyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester (0.01 mol) are dissolved in 10 ml of methanol and 1 g of hydrazine hydrate is added with stirring. After standing over night the title compound precipitates. Yield 2.1 g (73%); m.p. 120°-121° C. (methanol).

Workup

  1. waitAfter standing over night
  2. customthe title compound precipitates

Sources & evidence

ORD record
ord-2a5edcf58da04f2eb0e142db28bc347a
Source dataset
uspto-grants-1980_09
Patent number
US04223142

Reaction notes

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