1-(2-Methoxyphenyl)piperazine → HCID 22625352, compound

HRID 277645Notes

Reaction equation

HRID 277645 reaction equation
C([O:4][C:5]1[C:15]([CH3:16])=[CH:14][C:8]([O:9][CH2:10][CH:11]2[O:13][CH2:12]2)=[C:7]([CH3:17])[C:6]=1[CH3:18])(=O)C.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>O1CCOCC1>[CH3:17][C:7]1[C:6]([CH3:18])=[C:5]([OH:4])[C:15]([CH3:16])=[CH:14][C:8]=1[O:9][CH2:10][CH:11]([OH:13])[CH2:12][N:30]1[CH2:29][CH2:28][N:27]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[O:20][CH3:19])[CH2:32][CH2:31]1

Participants

4

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 13048747HCID 13048747, compound

Product 1

HCID 22625352HCID 22625352, compoundYield 33.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using 3.88 g of 1-(4-acetoxy-2,3,5-trimethylphenoxy)-2,3-epoxypropane, 3.58 g of 1-(2-methoxyphenyl)piperazine and 100 ml of dioxane, reaction and workup were carried out as in Examples 1-A and 4. After hydrolysis and workup, the residue obtained was recrystallized from benzene-hexane to give 2.06 g of white crystals, m.p. 163-165° C.

Workup

  1. customAfter hydrolysis and workup
  2. customthe residue obtained
  3. customwas recrystallized from benzene-hexane

Sources & evidence

ORD record
ord-b500ae80c5424c2c9001efb988aa871f
Source dataset
uspto-grants-2002_03
Patent number
US06358515B2

Reaction notes

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