反应详情

Using 2.5 g of methylhydroquinone and 2.8 g of benzoyl chloride, the procedure in Reference Example was followed. Recrystallization from ethanol-isopropyl ether gave 3.1 g of 4-benzoyloxy-2-methylphenol as white crystals, m.p. 120-122° C. Then, using 2.3 g of the crystals, 1.4 g of anhydrous potassium carbonate, 4.6 g of chloromethyloxirane and 1.9 g of 1-(2-methoxyphenyl)piperazine, the procedures of Examples 3 and 4 were followed to give 3.2 g of white crystals, m.p. 192-194° C. (decomp.).

1. customRecrystallization from ethanol-isopropyl ether