反应详情

Using 5.0 g of methylhydroquinone and 5.6 g of benzoyl chloride, the procedure of Reference Example was followed. Recrystallization from ethanol-isopropyl ether gave 6.2 g of 4-benzoyloxy-2-methylphenol as white crystals, m.p. 120-122. Then, using 6.2 g of thus obtained white crystals, 5.1 g of benzyl bromide and 4.1 g of anhydrous potassium carbonate, the procedure of Reference Example was followed to give 7.6 g of 1-benzyloxy-2-methyl-4-benzoyloxybenzene as white crystals, m.p. 118-119° C. Then, using 7.6 g of thus obtained white crystals, 15 ml of 2N NaOH and 100 ml of methanol, the procedure of Reference Example was followed to give 3.8 g of 4-benzyloxy-3-methylphenol as white crystals, m.p. 70-71° C. Then, using 2.1 g of thus obtained white crystals, 1.4 g of anhydrous potassium carbonate, 4.6 g of chloromethyloxirane and 1.9 g of 1-(2-methoxyphenyl)piperazine, the procedures of Examples 1-A and 2 were followed. Recrystallization from methanol-ethyl acetate gave 3.0 g of white crystals, m.p. 214-216° C. (decomp.).

1. customRecrystallization from ethanol-isopropyl ether