HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(2-Piperidin-1-yl-ethoxy)benzyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | amino alcohol 1-[2-(4-Hydroxymethyl-phenoxy)-ethyl]piperidine | HCID 69905497 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(2-Piperidin-1-yl-ethoxy)benzyl chloride | HCID 9860786 | — |
Reaction Steps
This material is prepared from the amino alcohol 1-[2-(4-Hydroxymethyl-phenoxy)-ethyl]piperidine by treatment with thionyl chloride in THF at 0° C. Resulting solid is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358943B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-cfd90462e41f402cb3877ca34c5d879c |
| Source note | uspto-grants-2002_03 |